When Marion went missing with $40,000 that she was to have deposited in the bank for George Lowery, Lila guessed that she may have gone to Fairvale to be with her boyfriend, Sam Loomis. Lila went to see Sam who had not seen Marion. She and Sam then pursued their own investigation with the help of Milton Arbogast.
Lila and Sam checked into the Bates Motel posing as husband and wife and discovered evidence that Marion had stayed there. Lila then snuck into the Bates house and discovered the corpse of Norma Bates. Her snooping had not gone unnoticed, as she was then attacked by Norman, who was in a dress and had earlier knocked out Sam in a fight. However, Lila was saved by Sam, who recovered and entered the basement of the Bates house in the nick of time, restraining Norman.
Sometime later, Lila married Sam Loomis and they had a daughter they named Mary in honour of Marion. Lila followed the story of Norman Bates' rehabilitation and when he was released 22 years after Marion's murder, she protested. She and her daughter then began a quest to drive Norman mad once again.
Lila and Mary took turns calling Norman, pretending to be his mother. They also dressed up as Norma Bates and left notes for Norman so that he would question his sanity. When Lila planned to dress up once more, she was murdered by Emma Spool in the cellar of the Bates House.